Overland Route from Osh to Fergana, Khujand, and Samarkand

From Fergana it’s easier to go to Kokand, and from there to Kanibadam, Khujand, Panjakent, and Samarkand. You can also cross the border from Khujand straight into Uzbekistan and go to Samarkand. Maybe someone can suggest a tried-and-tested route.

Right, I basically need to understand how and where to move. From the south to Andijan and further on it’s more or less clear, but from Osh to Fergana and then to Khujand there’s very little info ((

If via Kyrgyzstan, then Osh–Batken–Isfara–Khujand–Panjakent–Samarkand.
And if starting from Fergana, then Fergana–Kokand/–Kanibadam–Khujand and then the same further on.

Thanks, I’d really need the names of the border crossings and roughly the bus routes, or how long shared taxis usually take.

There’s nothing from Osh directly to Fergana, and Batken is quite a trek. Guliston checkpoint (Isfara), Kyzyl-Bel checkpoint (Batken).
Patar checkpoint (Kanibadam) — Andarkhan (Besharyk) to Kokand.
You can basically say there are no buses, only shared minibuses or taxis. In Khujand the bus station is the old one, there are lots of taxis to Panjakent, and from there further by taxi to the Sarazm–Jarteppa checkpoint. This is the border between Panjakent (RT) and Samarkand (RU). Be sure to bargain with the taxi drivers.

And how much does it cost and how long does it take to get from Khujand to Panjakent?

Roughly 100–140 somoni per person, travel time is about 4–5 hours if the weather allows. Depends on how lively the driver is)
Make an agreement with the taxi driver so that he drops you in Panjakent near the main market, by the market entrance (near the small door) there are taxi drivers who will take you to the Sarazm post for 15 somoni. After crossing the border, you need to bargain with the taxi drivers with real enthusiasm))), they can jack the price up x1.5–2, especially when they know you’re not local.
Also, at the market in Panjakent it’s better to exchange money into Uzbek sums, it’s more profitable to pay taxi drivers that way; often they themselves offer payment in somoni, but it’s better in sums. Also, when bargaining, you should emphasize that you will be paying in the Uzbek national currency. There have been cases where after the taxi driver takes you to the destination, he demands payment in somoni, like “I meant payment in somoni, otherwise I wouldn’t have agreed to that price.”